Thornhill JP
Barkati S
Walmsley S
et al. Monkeypox virus an infection in people throughout 16 international locations—April–June 2022. 2 Wenham C
Eccleston-Turner M Monkeypox as a PHEIC: implications for international well being governance. 3 Brown Okay
Leggat PA Human monkeypox: present state of data and implications for the long run. 1 Thornhill JP
Barkati S
Walmsley S
et al. Monkeypox virus an infection in people throughout 16 international locations—April–June 2022. , 4 Tarín-Vicente EJ
Alemany A
Agud-Dios M
et al. Medical presentation and virological evaluation of confirmed human monkeypox virus instances in Spain: a potential observational cohort research. Human monkeypox virus is spreading in Europe and the USA amongst people who haven’t travelled to endemic areas.On July 23, 2022, monkeypox was declared a Public Well being Emergency of Worldwide Concern by WHO Director-Basic Tedros Adhanom Ghebreyesus.Human-to-human transmission of monkeypox virus normally happens by shut contact with the lesions, physique fluids, and respiratory droplets of contaminated individuals or animals.The potential for sexual transmission is being investigated, as the present outbreak seems to be concentrated in males who’ve intercourse with males and has been related to sudden anal and genital lesions.Whether or not domesticated cats and canines could possibly be a vector for monkeypox virus is unknown. Right here we describe the primary case of a canine with confirmed monkeypox virus an infection that may have been acquired by human transmission.
Determine Pores and skin and mucosal lesions in two male sufferers and their canine with confirmed monkeypox virus Present full caption (A) Pustular lesion of the thigh, with central umbilication and the onset of necrosis, in affected person 1. (B) Erosive and pustular anal lesions in affected person 2. (C) Two barely crusty erythematous papules within the canine. (D) Millimetric erosive anal lesion within the canine. Two males who’ve intercourse with males attended Pitié-Salpêtrière Hospital, Paris, France, on June 10, 2022 ( appendix ). One man (known as affected person 1 going ahead) is Latino, aged 44 years, and lives with HIV with undetectable viral hundreds on antiretrovirals; the second man (affected person 2) is White, aged 27 years, and HIV-negative. The lads are non-exclusive companions dwelling in the identical family. They every signed a consent type for the usage of their scientific and organic knowledge, and for the publication of anonymised pictures. The lads had introduced with anal ulceration 6 days after intercourse with different companions. In affected person 1, anal ulceration was adopted by a vesiculopustular rash on the face, ears, and legs; in affected person 2, on the legs and again. In each instances, rash was related to asthenia, complications, and fever 4 days later ( determine A, B ).
Monkeypox virus was assayed by real-time PCR (LightCycler 480 System; Roche Diagnostics, Meylan, France). In affected person 1, virus was detected in pores and skin and oropharynx samples; whereas in affected person 2, virus was detected in anal and oropharynx samples.
5 Li Y
Zhao H
Wilkins Okay
Hughes C
Damon IK Actual-time PCR assays for the particular detection of monkeypox virus West African and Congo Basin pressure DNA. 12 days after symptom onset, their male Italian greyhound, aged 4 years and with no earlier medical issues, introduced with mucocutaneous lesions, together with stomach pustules and a skinny anal ulceration ( determine C, D appendix ). The canine examined constructive for monkeypox virus by use of a PCR protocol tailored from Li and colleaguesthat concerned scraping pores and skin lesions and swabbing the anus and oral cavity. Monkeypox virus DNA sequences from the canine and affected person 1 have been in contrast by next-generation sequencing (MinION; Oxford Nanopore Applied sciences, Oxford, UK). Each samples contained virus of the hMPXV-1 clade, lineage B.1, which has been spreading in non-endemic international locations since April, 2022, and, as of Aug 4, 2022, has contaminated greater than 1700 individuals in France, largely concentrated in Paris, the place the canine first developed signs. Furthermore, the virus that contaminated affected person 1 and the virus that contaminated the canine confirmed 100% sequence homology on the 19·5 kilobase pairs sequenced.
The lads reported co-sleeping with their canine. That they had been cautious to forestall their canine from contact with different pets or people from the onset of their very own signs (ie, 13 days earlier than the canine began to current cutaneous manifestations).
6 Khodakevich L
Jezek Z
Kinzanzka Okay Isolation of monkeypox virus from wild squirrel contaminated in nature. 7 Parker S
Buller RM A assessment of experimental and pure infections of animals with monkeypox virus between 1958 and 2012. 8 Arita I
Henderson DA Smallpox and monkeypox in non-human primates. In endemic international locations, solely wild animals (rodents and primates) have been discovered to hold monkeypox virus.Nevertheless, transmission of monkeypox virus in prairie canines has been described within the USAand in captive primates in Europethat have been in touch with imported contaminated animals. An infection amongst domesticated animals, akin to canines and cats, has by no means been reported.
To the very best oThornhill JP
Barkati S
Walmsley S
et al. Monkeypox virus an infection in people throughout 16 international locations—April–June 2022. 2 Wenham C
Eccleston-Turner M Monkeypox as a PHEIC: implications for international well being governance. 3 Brown Okay
Leggat PA Human monkeypox: present state of data and implications for the long run. 1 Thornhill JP
Barkati S
Walmsley S
et al. Monkeypox virus an infection in people throughout 16 international locations—April–June 2022. , 4 Tarín-Vicente EJ
Alemany A
Agud-Dios M
et al. Medical presentation and virological evaluation of confirmed human monkeypox virus instances in Spain: a potential observational cohort research. Human monkeypox virus is spreading in Europe and the USA amongst people who haven’t travelled to endemic areas.On July 23, 2022, monkeypox was declared a Public Well being Emergency of Worldwide Concern by WHO Director-Basic Tedros Adhanom Ghebreyesus.Human-to-human transmission of monkeypox virus normally happens by shut contact with the lesions, physique fluids, and respiratory droplets of contaminated individuals or animals.The potential for sexual transmission is being investigated, as the present outbreak seems to be concentrated in males who’ve intercourse with males and has been related to sudden anal and genital lesions.Whether or not domesticated cats and canines could possibly be a vector for monkeypox virus is unknown. Right here we describe the primary case of a canine with confirmed monkeypox virus an infection that may have been acquired by human transmission.
Determine Pores and skin and mucosal lesions in two male sufferers and their canine with confirmed monkeypox virus Present full caption (A) Pustular lesion of the thigh, with central umbilication and the onset of necrosis, in affected person 1. (B) Erosive and pustular anal lesions in affected person 2. (C) Two barely crusty erythematous papules within the canine. (D) Millimetric erosive anal lesion within the canine. Two males who’ve intercourse with males attended Pitié-Salpêtrière Hospital, Paris, France, on June 10, 2022 ( appendix ). One man (known as affected person 1 going ahead) is Latino, aged 44 years, and lives with HIV with undetectable viral hundreds on antiretrovirals; the second man (affected person 2) is White, aged 27 years, and HIV-negative. The lads are non-exclusive companions dwelling in the identical family. They every signed a consent type for the usage of their scientific and organic knowledge, and for the publication of anonymised pictures. The lads had introduced with anal ulceration 6 days after intercourse with different companions. In affected person 1, anal ulceration was adopted by a vesiculopustular rash on the face, ears, and legs; in affected person 2, on the legs and again. In each instances, rash was related to asthenia, complications, and fever 4 days later ( determine A, B ).
Monkeypox virus was assayed by real-time PCR (LightCycler 480 System; Roche Diagnostics, Meylan, France). In affected person 1, virus was detected in pores and skin and oropharynx samples; whereas in affected person 2, virus was detected in anal and oropharynx samples.
5 Li Y
Zhao H
Wilkins Okay
Hughes C
Damon IK Actual-time PCR assays for the particular detection of monkeypox virus West African and Congo Basin pressure DNA. 12 days after symptom onset, their male Italian greyhound, aged 4 years and with no earlier medical issues, introduced with mucocutaneous lesions, together with stomach pustules and a skinny anal ulceration ( determine C, D appendix ). The canine examined constructive for monkeypox virus by use of a PCR protocol tailored from Li and colleaguesthat concerned scraping pores and skin lesions and swabbing the anus and oral cavity. Monkeypox virus DNA sequences from the canine and affected person 1 have been in contrast by next-generation sequencing (MinION; Oxford Nanopore Applied sciences, Oxford, UK). Each samples contained virus of the hMPXV-1 clade, lineage B.1, which has been spreading in non-endemic international locations since April, 2022, and, as of Aug 4, 2022, has contaminated greater than 1700 individuals in France, largely concentrated in Paris, the place the canine first developed signs. Furthermore, the virus that contaminated affected person 1 and the virus that contaminated the canine confirmed 100% sequence homology on the 19·5 kilobase pairs sequenced.
The lads reported co-sleeping with their canine. That they had been cautious to forestall their canine from contact with different pets or people from the onset of their very own signs (ie, 13 days earlier than the canine began to current cutaneous manifestations).
6 Khodakevich L
Jezek Z
Kinzanzka Okay Isolation of monkeypox virus from wild squirrel contaminated in nature. 7 Parker S
Buller RM A assessment of experimental and pure infections of animals with monkeypox virus between 1958 and 2012. 8 Arita I
Henderson DA Smallpox and monkeypox in non-human primates. In endemic international locations, solely wild animals (rodents and primates) have been discovered to hold monkeypox virus.Nevertheless, transmission of monkeypox virus in prairie canines has been described within the USAand in captive primates in Europethat have been in touch with imported contaminated animals. An infection amongst domesticated animals, akin to canines and cats, has by no means been reported.
To the very best o
